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Do not give Viagra to anyone under 18 years old without medical advice. Oh, I haven't ever taken it, but I think the drug that tonyad mentioned is Cisapride, which got pulled for causing (I think) strokes?

Other common side effects of Viagra include warmth or redness in your face, neck, or chest; stuffy nose; headache; upset stomach; and back pain. In volunteers with severe (CLcr < 30 mL/min) renal impairment, sildenafil clearance was reduced, resulting in approximately doubling of AUC and Cmax compared to age-matched volunteers with no renal impairment [see DOSAGE AND ADMINISTRATION, and Use In Specific Populations].

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A: Viagra (sildenafil) works by inhibiting the chemical phosphodiesterase, which leads to an increase in the effect of nitric oxide. In volunteers with severe renal impairment (Clcr < 30 mL/min), sildenafil clearance was reduced, resulting in higher plasma exposure of sildenafil (~2 fold), approximately doubling of Cmax and AUC. The patent for Viagra (sildenafil) will not expire until 2012; therefore, no generic, less expensive form is currently available.

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Co-administration of saquinavir, a strong CYP3A4 inhibitor, resulted in 140% and 210% increases in sildenafil Cmax and AUC, respectively. For people with pulmonary veno-occlusive disease (PVOD): Taking this drug may worsen your heart function. In this study, researchers looked at the effects of treating ED with Viagra in a carefully selected group of 35 men with mild to moderate heart failure who did not use nitates. If your husband has been experiencing difficulty sleeping, you may want to consult with the physician to determine the underlying cause and possible treatment options, if necessary. Availability Not every pharmacy stocks this drug.

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Especially tell your healthcare provider if you take any of the following: VIAGRA does not protect against sexually transmitted diseases, including HIV. Avoid the use of grapefruit products while taking Viagra. Arnold, have stated in the Annals of Pharmacotherapy that "the drug has been suggested as a contributing factor in 22 cases involving aggression, 13 involving rape, and 6 involving murder." Clearly, Viagra is linked to violence against women. These doses represent, respectively, about 20 and 40 times the Maximum Recommended Human Dose (MRHD) on a mg/m² basis in a 50 kg subject. Pfizer has helped to reinforce these traditional and not-so-traditional ideals with Viagra and it has been fascinating to see how successful they have been here and around the world with this youth, vitality, and performance-based message. Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA "Oral sildenafil in the treatment of erectile dysfunction." N Engl J Med 338 (1998): 1397-404 33. Zrenner E "No cause for alarm over retinal side-effects of sildenafil." Lancet 353 (1999): 340-1 45. If Viagra is consumed alongside a meal with a high-fat content, it will take much longer for the medication to work. Many of these sites do not contain the medication you are paying for. Conversely, flibanserin works to raise levels of dopamine and norepinephrine to promote desire and arousal. Figure 1: Mean Change from Baseline in Sitting Systolic Blood Pressure, Healthy Volunteers Effects of VIAGRA on Blood Pressure When Nitroglycerin is Subsequently Administered Based on the pharmacokinetic profile of a single 100 mg oral dose given to healthy normal volunteers, the plasma levels of sildenafil at 24 hours post dose are approximately 2 ng/mL (compared to peak plasma levels of approximately 440 ng/mL).