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The major circulating metabolite results from N-desmethylation of sildenafil, and is itself further metabolized. By inhibiting phosphodiesterase, Viagra enhances the effect of nitric oxide allowing for smooth muscle relaxation and increasing blood flow to specific areas of the body in the presence of sexual arousal or stimulation. Clinical Pharmacology CLINICAL PHARMACOLOGY Mechanism Of Action The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. When you take the drug depends on the condition being treated: For ED: You can take this drug at any time of day. Do not take Viagra (sildenafil) if you are also using a nitrate drug for chest pain or heart problems. When they looked at the individual measures, they found women treated with Viagra were significantly more likely to reach orgasm than those in the placebo group.

I started out with 50 mg of Viagra, after about two years I moved up to 100 mg. A: Viagra (sildenafil) belongs to a class of medications, known as phosphodiesterase inhibitors, which are indicated for the treatment of erectile dysfunction in men. However, since higher plasma levels may increase the incidence of adverse reactions, a starting dose of 25 mg should be considered in older subjects due to the higher systemic exposure [see DOSAGE AND ADMINISTRATION].

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The side effects included headaches, dizziness and just being tired. When your doctor prescribes a new medication, be sure to discuss all your prescription and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals, and herbals, as well as the foods you eat. This information is not a substitute for medical advice.

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There are some less common side effects that affect 2-3% of men. Read More I am currently on 10mg of Nadolol and I've noticed that I can go days and weeks without getting a palp and then a week before my period or so I can get about 50 or so palps in one day! Each trial lasted 24 weeks and evaluated the efficacy of flibanserin compared to placebo in premenopausal women. A: Viagra (sildenafil) is a prescription medication used to treat erectile dysfunction.

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Erections do not last for four hours, however, a man has the ability to have an erection for up to four hours. Many of these sites do not contain the medication you are paying for. Wie Oath und unsere Partner Ihnen bessere Werbung anbieten Um Ihnen insgesamt ein besseres Nutzererlebnis zu bieten, möchten wir relevante Anzeigen bereitstellen, die für Sie nützlicher sind. Viagra (also known as sildenafil citrate) belongs to a group of medicines known as PDE5 inhibitors, and like all of these medicines, there are side effects. Patti Brown, PharmD Q: When might a generic version of Viagra be available? Always keep a current list of the drugs and supplements you take and review it with your health care providers and your pharmacist. The primary measure in the principal studies was a sexual function questionnaire (the International Index of Erectile Function -IIEF) administered during a 4-week treatment-free run-in period, at baseline, at follow-up visits, and at the end of double-blind, placebo-controlled, at-home treatment.