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A: The maximum recommended dose for Viagra (sildenafil), used to treat ED (erectile dysfunction), is 100 mg per day. Also we know that one of the main sx.of liver disease left untreated can be a devastating one all on its own.

Follow all directions on your prescription label. However, since higher plasma levels may increase the incidence of adverse reactions, a starting dose of 25 mg should be considered in older subjects due to the higher systemic exposure [see DOSAGE AND ADMINISTRATION].

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While the precise biological actions of sildenafil in the heart are not fully understood, the drug is known to work by stopping the action of an enzyme, called phosphodiesterase 5 (PDE5A), the researcher says.  This enzyme is involved in the breakdown of a key molecule, cyclic GMP, which helps control stresses and limit overgrowth in the heart.  PDE5A is also the biological pathway blocked in the penis by sildenafil to promote the relaxation of blood vessels and maintain erections.  Funding for this study was provided by the National Institutes of Health (NIH), the Peter Belfer Laboratory Foundation and the Bernard Family Foundation.  The makers of the drug had no involvement in the design or support of the research. Total maximum savings for this offer is $4200 per year.Effects Dosage History It works by relaxing the muscles in the walls of blood vessels in certain areas of the body. VIAGRA (50 mg) did not potentiate the increase in bleeding time caused by aspirin (150 mg). Nitrate drugs such as nitroglycerin and isosorbide dinitrate (which are commonly used to treat chest pain) do not mix well with Viagra, and the complications can be dangerous. Punching and usda, choosing to 12 viagra and alcohol side effects weeks gestation mdash, contradicted not otherwise healthy tissue that i?m not known for the traditional storytellers known as companies conduct an add-on. Thereafter, 17 subjects were treated with VIAGRA 25 mg or matching placebo in combination with doxazosin 4 mg (15 subjects) or doxazosin 8 mg (2 subjects).

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He has had no ill effects from taking it since but there have been times when he has not taken it that he has a severe headache after he orgasms. The major circulating metabolite results from N-desmethylation of sildenafil, and is itself further metabolized. This is essentially a different type of Viagra which is used for a different FDA approved indication.

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When sexual stimulation occurs, nitric oxide is released by the nervous system in the erectile tissue of the penis. For example, you should know that Viagra should be taken on an empty stomach an hour before sex. Do you have any other physical conditions that may be causing it, such as other vascular problems, issues with nerves that send the arousal signal from the brain and spinal cord to the penis (common in diabetes), problems with the structure of the penis or the surrounding tissue, low testosterone, or use of tobacco, alcohol, or illegal drugs? They can also include erections that last longer than normal. Do not believe what you read on the Internet or the great prices you see. Kloner RA, Zusman RM "Cardiovascular effects of sildenafil citrate and recommendations for its use." Am J Cardiol 84 (1999): n11-7 21. Likewise, if you have low blood pressure or uncontrolled and unregulated high blood pressure (hypertension), you should refrain from taking Viagra 150 mg pills or any other PDE5 inhibitors.