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The major circulating metabolite results from N-desmethylation of sildenafil, and is itself further metabolized. All three of these medications inhibit an enzyme (PDE-5) that breaks down the substance produced by the penile tissue in response to sexual stimulation, and helps the erection occur. This allows your pharmacist to keep a complete record of all your prescription drugs and to advise you about drug interactions and side effects. Consult your physician or healthcare provider for specific recommendations on potential alternatives to Viagra treatment.

Please see full prescribing information for VIAGRA (25 mg, 50 mg, 100 mg) tablets. As you get older, Viagra leaves your body more slowly. Read More April 1, 2010 (Nuthetal, Germany) — The largest observational study so far to examine the association between chocolate consumption and risk of cardiovascular disease has found that those who ate the most chocolate--around 7.

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Pharmacodynamics Effects of VIAGRA on Erectile Response In eight double-blind, placebo-controlled crossover studies of patients with either organic or psychogenic erectile dysfunction, sexual stimulation resulted in improved erections, as assessed by an objective measurement of hardness and duration of erections (RigiScan®), after VIAGRA administration compared with placebo. Consistent with its known effects on the nitric oxide/cGMP pathway, VIAGRA was shown to potentiate the hypotensive effects of nitrates [see DOSAGE AND ADMINISTRATION, CONTRAINDICATIONS, CLINICAL PHARMACOLOGY]. Pfizer has since said in a statement that it was not involved in the Dutch or Queensland trials. In the year 2000, Viagra (sildenafil) reportedly accounted for 92% of the global market for prescribed erectile dysfunction pills. Lori Mendoza, PharmD Q: Are there different types of Viagra? It is always good to ask your doctor or pharmacist about the most common side effects that you can expect.

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It is not possible to determine whether these events are related directly to VIAGRA, to sexual activity, to the patient's underlying cardiovascular disease, to a combination of these factors, or to other factors [see WARNINGS AND PRECAUTIONS and PATIENT INFORMATION]. However, there aren’t enough studies done in humans using the drug for PAH to show if the drug poses a risk to the fetus.

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Osol says that when given to pregnant rats with induced hypertension, Viagra: Helped arteries of the uterus grow as they should during pregnancy. "Hypertension decreases the growth and alters contractility of blood vessels in the uterus," Osol says, "but giving Viagra reversed these effects, resulting in improved function of the uterine circulation." Arterial diameters of Viagra-treated animals didn't quite match control (normal) values, "but were significantly larger than those with hypertension, suggesting that it may have increased blood flow to the uterus and placenta," Osol adds. Viagra (sildenafil) is an oral drug that is used for treating impotence (or erectile disfunction, ED, the inability to attain or maintain a penile erection). You can also find helpful information on erectile dysfunction at //www.everydayhealth.com/erectile-dysfunction/guide/. If you are over 65 years old, you may find that the medication stays in your body for longer. It’s linked with the development of female sexual characteristics and reproduction. This includes maintaining an erection for up to 4 hours and working within 60 minutes of digestion. Some medications can change how long the effects of Viagra last. By taking Viagra on an empty stomach, the effects could start sooner Alcohol. Sixty-three percent, 74%, and 82% of the patients on 25 mg, 50 mg and 100 mg of VIAGRA, respectively, reported an improvement in their erections, compared to 24% on placebo. Therefore your overall cardiovascular status needs to be considered when you contemplate taking Viagra.