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This includes nitroglycerin (Nitrostat, Nitrolingual, Nitro-Dur, Nitro-Bid, and others), isosorbide dinitrate (Dilatrate-SR, Isordil, Sorbitrate), and isosorbide mononitrate (Imdur, ISMO, Monoket). Drug Interaction Studies Effects of Other Drugs on VIAGRA Sildenafil metabolism is principally mediated by CYP3A4 (major route) and CYP2C9 (minor route). Safety and effectiveness have not been established in pediatric patients.

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