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Taking sildenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure. Cardiovascular and Cerebrovascular Serious cardiovascular, cerebrovascular, and vascular events, including myocardial infarction, sudden cardiac death, ventricular arrhythmia, cerebrovascular hemorrhage, transient ischemic attack, hypertension, subarachnoid and intracerebral hemorrhages, and pulmonary hemorrhage have been reported post-marketing in temporal association with the use of VIAGRA. Metabolism and Excretion Sildenafil is cleared predominantly by the CYP3A4 (major route) and CYP2C9 (minor route) hepatic microsomal isoenzymes. They were, in fact, working on a drug for hypertension, or high blood pressure, and angina pectoris, a symptom of ischemic heart disease.

Read More JSGeare, you make an interesting point about weighing how I felt on the Lexapro vs. the side effects. Get your Kindle here, or download a FREE Kindle Reading App. A: Viagra (sildenafil) must be used with caution in patients taking an antihypertensive medication. The incidents include abnormal heart rhythm (atrial fibrillation and ventricular arrhythmia), low blood pressure, myocardial infarction, and blood clots (thromboembolism). A pill for sexual potency can be a dangerous thing in a culture that is highly ambivalent about sexuality—both obsessed and disgusted with it at the same time. You can also find helpful information on erectile dysfunction at //www.everydayhealth.com/erectile-dysfunction/guide/.

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A: Viagra (sildenafil) is used for the treatment of erectile dysfunction. The erectile response, as assessed by RigiScan®, generally increased with increasing sildenafil dose and plasma concentration. For people with eye problems: This drug may cause sudden loss of vision in one or both eyes. In the rat pre-and postnatal development study, the no observed adverse effect dose was 30 mg/kg/day given for 36 days. Most importantly, you should talk about the drug, your medical history and your concerns with your doctor. In this study, researchers looked at the effects of treating ED with Viagra in a carefully selected group of 35 men with mild to moderate heart failure who did not use nitates.

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Clinical data have shown that co-administration with saquinavir or erythromycin increased plasma levels of sildenafil by about 3 fold [see DRUG INTERACTIONS and CLINICAL PHARMACOLOGY]. D., a professor at The Johns Hopkins University School of Medicine and its Heart Institute.  “Sildenafil effectively puts a ‘brake’ on chemical stimulation of the heart,” says Kass.  The researchers’ findings, which appear in the journal Circulation online Oct. The pattern of responses was similar for the other principal question, the ability to achieve an erection sufficient for intercourse.

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Avoid using any other medicines to treat impotence, such as alprostadil or yohimbine, without first talking to your doctor. One or two glasses of wine or beer shouldn’t have too much of a detrimental effect, although results will vary from person to person. There was one subject with a decrease from baseline in standing systolic BP > 30mmHg following VIAGRA 50 mg and one subject with a decrease from baseline in standing systolic BP > 30 mmHg following both VIAGRA 50 mg and placebo. When the drug leaves the body, it does so by being filtered out through a specific pathway in the liver. Viagra was initially designed to help lower blood pressure but is now typically used to treat erectile dysfunction. If these occur, you should contact your healthcare provider.