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In a study of healthy male volunteers, co-administration of sildenafil at steady state (80 mg t.i.d.) with endothelin receptor antagonist bosentan (a moderate inducer of CYP3A4, CYP2C9 and possibly of CYP2C19) at steady state (125 mg b.i.d.) resulted in a 63% decrease of sildenafil AUC and a 55% decrease in sildenafil Cmax . They can also include erections that last longer than normal.

Effects on the prostate According to some sources, alcohol abuse may be associated with prostatitis (inflammation of the prostate gland). Before you take VIAGRA, tell your healthcare provider if you: have or have had heart problems such as a heart attack, irregular heartbeat, angina, chest pain, narrowing of the aortic valve or heart failure have had heart surgery within the last 6 months have pulmonary hypertension have had a stroke have low blood pressure, or high blood pressure that is not controlled have a deformed penis shape have had an erection that lasted for more than 4 hours have problems with your blood cells such as sickle cell anemia, multiple myeloma, or leukemia have retinitis pigmentosa, a rare genetic (runs in families) eye disease have ever had severe vision loss, including an eye problem called non-arteritic anterior ischemic optic neuropathy (NAION) have bleeding problems have or have had stomach ulcers have liver problems have kidney problems or are having kidney dialysis have any other medical conditions Tell your healthcare provider about all the medicines you take*, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Individuals taking alpha-blockers should make sure they take Viagra at least 4 hours before or after taking alpha-blockers.

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You must always mention these conditions during a doctor assessment for Viagra treatment Drug interactions. Some people may also have ringing in their ears (tinnitus) or dizziness. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action.

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If you are taking another erectile dysfunction treatment that is a lower dosage than 50mg for a particular reason, it is advised to consult your doctor beforehand. A study looked at the effects of taking 100 mg of Viagra in a single dose, which resulted in a decrease of 8. Michelle McDermott, PharmD Q: My urologist has prescribed 100 mg of Viagra for my erectile dysfunction.

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Due to age-differences in plasma protein binding, the corresponding increase in the AUC of free (unbound) sildenafil and its active N-desmethyl metabolite were 45% and 57%, respectively [see CLINICAL PHARMACOLOGY]. Most, but not all of these men, had heart problems before taking this medication. It works by allowing increased blood flow to the penis, which causes an erection. Viagra should be used with caution in patients with heart disease, including arrhythmias (abnormal heart rhythms); a recent history (in the past 6 months) of a heart attack, stroke, or heart rhythm disorder; congestive heart failure; high or low blood pressure; and coronary artery disease.