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Kimberly Hotz, PharmD Q: Is there a generic for Viagra? Senior dosage (ages 65 years and older) The kidneys, liver, or heart of older adults may not work as well as they used to. Stepwise increase in alpha-blocker dose may be associated with further lowering of blood pressure when taking a PDE5 inhibitor.

Clinical Studies In clinical studies, VIAGRA was assessed for its effect on the ability of men with erectile dysfunction (ED) to engage in sexual activity and in many cases specifically on the ability to achieve and maintain an erection sufficient for satisfactory sexual activity. If you have liver or kidney problems, Viagra’s effects could last for longer, although it might not be safe to take Viagra with these conditions. Allergy warning Sildenafil can cause a severe allergic reaction.

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You can buy VIAGRA connect at the pharmacy, from registered online pharmacies or through this VIAGRA connect website. Doses may range from 5 mg to 20 mg depending on efficacy and patient tolerability.

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By inhibiting phosphodiesterase, Viagra enhances the effect of nitric oxide allowing for smooth muscle relaxation and increasing blood flow to specific areas of the body in the presence of sexual arousal or stimulation. A doctor’s assessment will help you find the right dosages for you General health. It is important to avoid nitroglycerin while taking these medications, but work is being done to develop a similar medication that can be taken with nitroglycerin. Viagra has spurred several like products – Cialis and Levitra.

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While the precise biological actions of sildenafil in the heart are not fully understood, the drug is known to work by stopping the action of an enzyme, called phosphodiesterase 5 (PDE5A), the researcher says.  This enzyme is involved in the breakdown of a key molecule, cyclic GMP, which helps control stresses and limit overgrowth in the heart.  PDE5A is also the biological pathway blocked in the penis by sildenafil to promote the relaxation of blood vessels and maintain erections.  Funding for this study was provided by the National Institutes of Health (NIH), the Peter Belfer Laboratory Foundation and the Bernard Family Foundation.  The makers of the drug had no involvement in the design or support of the research. Visit MedWatch or call 1-800-FDA-1088. *Eligibility required. In the nonpregnant rat the AUC at this dose was about 20 times human AUC. A total dose of 40 mg sildenafil was administered by four intravenous infusions. Non-arteritic anterior ischemic optic neuropathy (NAION), a cause of decreased vision including permanent loss of vision, has been reported rarely post-marketing in temporal association with the use of phosphodiesterase type 5 (PDE5) inhibitors, including VIAGRA. When vasodilators are used in combination, an additive effect on blood pressure may occur. Prolonged Erection And Priapism Prolonged erection greater than 4 hours and priapism (painful erections greater than 6 hours in duration) have been reported infrequently since market approval of VIAGRA. Drinking alcohol lowers blood pressure – and so does taking Viagra. A: Viagra (sildenafil) is used for the treatment of erectile dysfunction. All three of these medications inhibit an enzyme (PDE-5) that breaks down the substance produced by the penile tissue in response to sexual stimulation, and helps the erection occur.