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A: Taking Viagra twice a day is not necessarily a problem for some people. Viagra's meteoric rise to fame has seen it enter usage as an illicit drug. This is because the fat in your digestive system causes the medication to enter your blood more slowly. Sildenafil is only about 10-fold as potent for PDE5 compared to PDE6, an enzyme found in the retina which is involved in the phototransduction pathway of the retina.

Studies have produced relevant data on the effects of VIAGRA on cardiac output. Sexual activity can put an extra strain on your heart, especially if your heart is already weak from a heart attack or heart disease. The study started in 2015 and involved 11 hospitals. Medications for hypertension (high blood pressure) are usually fine to take with it, as far as drug interactions go.

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Clinical Studies In clinical studies, VIAGRA was assessed for its effect on the ability of men with erectile dysfunction (ED) to engage in sexual activity and in many cases specifically on the ability to achieve and maintain an erection sufficient for satisfactory sexual activity. If you believe you have had more than the standard dosage, call a doctor or local Poison Control Center. symptoms of an overdose might include: vomiting blurred vision and distorted vision papilledema - swelling in the optic nerve optic neuropathy - damage to the optic nerve tachycardia (increased heart rate) prolonged priapism blindness rhabdomyolysis - break down of muscles diarrhea Deaths from viagra overdose are rare but possible.

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Drugs you should not use with sildenafil Do not take these drugs with sildenafil. Here are just a few of the ingredients found in counterfeit medicines: Brick dust Rat poison Boric acid Antifreeze Floor wax Mercury Lead Arsenic Road paint Too much or too little active ingredient, or no active ingredient at all How can I be sure an online pharmacy is genuine?

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Alcohol interaction warning The use of drinks that contain alcohol raises your risk of low blood pressure from sildenafil. Mutagenesis Sildenafil was negative in in vitro bacterial and Chinese hamster ovary cell assays to detect mutagenicity, and in vitro human lymphocytes and in vivo mouse micronucleus assays to detect clastogenicity. If you experience chest pain, dizziness, or nausea during sex, seek immediate medical help. NHS choices Is there such a thing as “Herbal VIAGRA connect”? Patients should be stable on alpha-blocker therapy prior to initiating a PDE5 inhibitor. Do not take VIAGRA if you take any other medicines called “nitrates.” Nitrates are used to treat chest pain (angina). Viagra is useful not just in treating impotence but in treating premature ejaculation, and it is estimated that over 40% of men worldwide could benefit from taking the drug. Sexual function data were also recorded by patients in a daily diary.